ABSTRACT
A phytochemical study of the ethanol extract and an extraction of the volatile compounds, performed by means of Clevenger apparatus were carried out with the stem of Fusaea longifolia (Aubl.) Saff. (Annonaceae). The ethanol extract yielded O-methylmoschatoline, isolated for the first time in this species, and stepholidine, reported for the first time in genus Fusaea. The structural identification of the alkaloids was made based on the analysis of their NMR spectra. Through the use of GC and GC-MS, two sesquiterpenoids, a-cadinol (12.5 percent) and spatulenol (12.0 percent) were identified as the major constituents of the essential oil.
ABSTRACT
O extrato hexânico das cascas do caule de Diplotropis ferruginea Benth (Fabaceae), após procedimentos cromatográficos e fitoquímicos, forneceu o triterpeno lupeol, citado pela primeira vez em Diplotropis ferruginea, e etil-2-hidroxi-4-methoxi-6-propil-benzoate, descrito pela primeira vez em na literatura. As determinações estruturais desses compostos foram realizadas com base em análises espectroscópicas de ¹H e 13C NMR, bem como também por comparação com valores da literatura.
The hexane extract of the stem bark of Diplotropis ferruginea Benth (Fabaceae), after chromatografic and phytochemical procedures, yielded the triterpene lupeol, wich has been cited for the first time on Diplotropis ferruginea, and ethyl-2-hydroxy-4-methoxy-6-propyl-benzoate, described for the first time on literature. The structural determinations of these compounds were performed on the basis of ¹H and 13C NMR spectroscopic analysis as well as comparison with literature values.
ABSTRACT
Três alcalóides benzilisoquinolínicos, reticulina, coclaurina e N-acetilnorjuzifina foram isolados das cascas de caule de Ocotea duckei; do cálice foi isolado laureliptina, um alcalóide do tipo aporfínico. Essas substâncias foram isoladas por métodos cromatográficos e identificadas por espectroscopia de 1H e 13C NMR com o auxílio de técnicas 2-D como as de COSY, NOESY, HMQC e HMBC. Comparações com os dados de literatura foram também realizadas.
Three benzylisoquinoline alkaloids, reticuline, coclaurine, and N-acetyl norjuziphine, where isolated from the stem bark of Ocotea duckei, the calix yielded laurelliptine, an aporphine alkaloid. These substances were isolated by chromatographic methods and identified by 1H and 13C NMR spectroscopy with the aid of 2-D techniques such as COSY, NOESY, HMQC and HMBC. Comparison with literature data was also helpful.
ABSTRACT
From the ethanolic extract of the leaves and thin branches of Duguetia trunciflora Maas (Annonaceae) six alkaloids were isolated, being one benzylisoquinoline: reticuline¹, four tetrahydroprotoberberine:,tetrahydro-palmatine², tetrahydrojathrorrizine³, discretamine4, thaicanine5, and one berberine: jathrorrizine6. These alkaloids were identified through ¹H and 13C NMR spectroscopic technics. The alkaloids 1, 3, 5 and 6 are being cited for the first time on Duguetia genus.
ABSTRACT
The genus Hornschuchia obliqua belonging to the Annonaceae family. The family comprising ca 130 genera and 2300 species, located in the Magnoliales, a primitive order of plants, is known to produce isoquinoline alkaloids derivatives1. Indeed the great majority of alkaloidal constituents of these plants are isoquinoline-derived structures, along with a wide range of non-alkaloidal compounds of varied stuctural types2,3. The present paper describes the chemical investigation of the alkaloids from Hornschuchia obliqua, isolated until now.
ABSTRACT
Uma investigação fitoquímica das vagens de Prosopis juliflora cultivada na região semi-árida do Estado da Paraíba e monitorada através de testes farmacológicos levou ao isolamento, purificação e identificação do alcalóide principal juliprosopina. A presença de outros constituintes químicos em mistura, tais como juliprosina e juliprosineno, foi verificada na fração dos alcalóides totais através de uma análise do espectro de RMN de 13C. Este trabalho sugere que a toxicidade, observada em animais de laboratório, está quimicamente relacionada com os alcalóides piperidínicos presentes nas vagens desta leguminosa.
A phytochemical investigation of the pods of Prosopis juliflora cultivated in the semi arid region of the State of Paraiba, monitored by pharmacological tests, led to the isolation, purification and identification of its main alkaloid - juliprosopine. The presence of other compounds such as juliprosine and juliprosinene, was observed through analysis of 13C NMR. This work suggests that the toxic activity, observed in laboratory animals, is chemicaly related with the piperidine alkaloids present in the pods of this Leguminosae.
ABSTRACT
A systematic search for solasodine, an important staring material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliforum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showe durare like activity yelded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yelded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and exitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity.